Transcriptional Control of Tissue of Homeostasis

Research topic(s)

The von Eyss lab (FLI, Jena)External link investigates the Hippo pathway in the context of aging, regeneration and cancer. They mainly focus on the two paralogous downstream transducers of this pathway, the coactivator proteins YAP and TAZ. YAP/TAZ are critical for regenerative processes in multiple tissues since deletion of these genes leads to a strongly impaired tissue repair upon damage. Genetically increasing YAP/TAZ activity can be exploited in order to induce regeneration in tissue which normally show a weak regenerative capacity. Since aging is accompanied by a gradual loss of regenerative potential in multiple – if not all – tissues, they aim at identifying specific upstream regulators and critical downstream targets of YAP/TAZ to counteract this phenomenon. In summary, the group aims to elucidate the in vivo functions of the Hippo pathway in aging, regeneration and cancer and to identify new avenues for its modulation.

Methods

• Functional genomics
• Transcriptomics
• Single-cell biology
• Mouse models

Selected Publications

Flohr Svendsen A, Yang D, Kim K, Lazare S, Skinder N, Zwart E, Mura-Meszaros A, Ausema A, von Eyss B, de Haan G, Bystrykh L. (2021) A comprehensive transcriptome signature of murine hematopoietic stem cell aging.External link Blood, 138(6):439-451

Elster* D, Tollot* M, Schlegelmilch K, Ori A, Rosenwald A, Sahai E, von Eyss B. (2018) TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells.External link Nat Commun, 9(1):3115 (*equal contribution)

Elster D, Jaenicke LA, Eilers M, von Eyss B. (2016) TEAD activity is restrained by MYC and stratifies human breast cancer subtypesExternal link. Cell Cycle, 15(19):2551-2556

 Jaenicke* LA, von Eyss* B, Carstensen A, Wolf E, Xu W, Greifenberg AK, Geyer M, Eilers M, Popov N. (2016) Ubiquitin-dependent turnover of MYC antagonizes MYC/PAF1C complex accumulation to drive transcriptional elongationExternal link. Mol Cell, 61(1):54-67 (*equal contribution)

von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M. (2015) A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancerExternal link. Cancer Cell, 28(6):743-757

Links

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